Glyoxalase Inhibitors. A Possible Approach to Anticancer Agents

Robert Vince, Susan Daluge

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Some glyoxalase I enzyme inhibitors were assayed for cytotoxic activity against L1210 leukemia and KB cells in tissue culture. Sublethal concentrations of glyoxalase inhibitor caused a 14- to 18-fold increase in methylglyoxal toxicity in L1210 cells. A probable mechanism for the cytotoxic activity of methylglyoxal is discussed.

Original languageEnglish (US)
Pages (from-to)35-37
Number of pages3
JournalJournal of medicinal chemistry
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1971

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