Glycolytic genes in cancer cells are more than glucose metabolic regulators

Zhe Yu Hu, Lanbo Xiao, Ann M. Bode, Zigang Dong, Ya Cao

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Nearly a hundred years of scientific research has revealed a notable preference of cancer cells to utilize aerobic glycolysis rather than mitochondrial oxidative phosphorylation for glucose-dependent ATP production, which is thought to be the root of tumor formation and growth. Glycolysis is a complex biochemical process that is mediated by multiple glycolytic genes. Besides regulating glucose metabolism, these genes are also suggested to possess various other functions related to cancer, including roles in cancer development and promotion, inhibition of apoptosis, cell cycle progression, and tumor metastasis. This article highlights the biological functions of glycolytic genes beyond their role in regulation of glycolysis and discusses their clinical implications, especially in regard to the use of glycolytic genes as biomarkers for early detection of cancer or as targets for novel anticancer treatments.

Original languageEnglish (US)
Pages (from-to)837-845
Number of pages9
JournalJournal of Molecular Medicine
Volume92
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Clinical use
  • Glycolytic enzymes
  • Multiple functions in cancers

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