Glycemic and lipid responses to glucomannan in Thais with type 2 diabetes mellitus

Supornpim Chearskul, Somkiat Sangurai, Wannee Nitiyanant, Wantanee Kriengsinyos, Suwattanee Kooptiwut, Tasma Harindhanavudhi

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20 Scopus citations


Objective: To evaluate the benefits of glucomannan supplement on glycemic and lipid controls in type 2 diabetic patients. Material and Method: A single-blind, placebo-controlled, crossover trial with two treatments separated by a 2-week washout period was performed in 10 men and 10 women with type 2 diabetes mellitus. Two separated protocols of experiments were sequentially followed. Initially, purified glucomannan (1 g) or placebo was ingested 30 min before 75-g glucose load to evaluate their effects on glucose absorption and insulin secretion in oral glucose tolerance test (OGTT). Later, the glycemic and lipid changes after 4-week intervention with 3 g/day glucomannan comparing to the placebo were determined. The standard OGTT was performed before and after ending of each intervention. Results: Glucomannan taken before performing the OGTT can lower the rise of blood glucose and insulin from 1 to 2 hour in comparison with the placebo, though a statistically significance of insulin was not achieved. Long- term glucomannan supplement significantly reduced the 120-min glucose area under the curve of OGTT. Glucomannan also decreased the rise of low-density lipoprotein cholesterol (LDL-C). Reductions of HOMA-insulin resistance index and body mass index were detected in glucomannan-treated group though the former was shown only in females. No within- and between-group differences of insulin, fructosamine, and other lipids were observed in glucomannan- nor placebo- treated groups. Conclusion: In type 2 diabetes, pre-prandial glucomannan ingestion attenuated a rise of blood glucose without significantly affecting insulin levels. Long-term supplement of glucomannan to the regular diabetic regimen lessened post challenge glucose AUC and impeded the rise of LDL-C. Supplement of glucomannan may be beneficial to the glycemic and lipid controls in type 2 diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)2150-2157
Number of pages8
JournalJournal of the Medical Association of Thailand
Issue number10
StatePublished - Oct 2007


  • Glucomannan
  • OGTT
  • Soluble dietary fiber
  • Thais
  • Type 2 diabetes


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