Glutamatergic facilitation of neural responses in MT enhances motion perception in humans

Michael-Paul Schallmo, Rachel Millin, Alex M. Kale, Tamar Kolodny, Richard A.E. Edden, Raphael A. Bernier, Scott O. Murray

Research output: Contribution to journalArticle

Abstract

There is large individual variability in human neural responses and perceptual abilities. The factors that give rise to these individual differences, however, remain largely unknown. To examine these factors, we measured fMRI responses to moving gratings in the motion-selective region MT, and perceptual duration thresholds for motion direction discrimination. Further, we acquired MR spectroscopy data, which allowed us to quantify an index of neurotransmitter levels in the region of area MT. These three measurements were conducted in separate experimental sessions within the same group of male and female subjects. We show that stronger Glx (glutamate + glutamine) signals in the MT region are associated with both higher fMRI responses and superior psychophysical task performance. Our results suggest that greater baseline levels of glutamate within MT facilitate motion perception by increasing neural responses in this region.

LanguageEnglish (US)
Pages925-931
Number of pages7
JournalNeuroImage
Volume184
DOIs
StatePublished - Jan 1 2019

Fingerprint

Motion Perception
Glutamic Acid
Magnetic Resonance Imaging
Aptitude
Task Performance and Analysis
Glutamine
Individuality
Neurotransmitter Agents
Magnetic Resonance Spectroscopy
Discrimination (Psychology)
Direction compound

Keywords

  • Functional MRI
  • Glutamate
  • Individual differences
  • MR spectroscopy
  • Vision

PubMed: MeSH publication types

  • Journal Article

Cite this

Schallmo, M-P., Millin, R., Kale, A. M., Kolodny, T., Edden, R. A. E., Bernier, R. A., & Murray, S. O. (2019). Glutamatergic facilitation of neural responses in MT enhances motion perception in humans. NeuroImage, 184, 925-931. https://doi.org/10.1016/j.neuroimage.2018.10.001

Glutamatergic facilitation of neural responses in MT enhances motion perception in humans. / Schallmo, Michael-Paul; Millin, Rachel; Kale, Alex M.; Kolodny, Tamar; Edden, Richard A.E.; Bernier, Raphael A.; Murray, Scott O.

In: NeuroImage, Vol. 184, 01.01.2019, p. 925-931.

Research output: Contribution to journalArticle

Schallmo, Michael-Paul ; Millin, Rachel ; Kale, Alex M. ; Kolodny, Tamar ; Edden, Richard A.E. ; Bernier, Raphael A. ; Murray, Scott O. / Glutamatergic facilitation of neural responses in MT enhances motion perception in humans. In: NeuroImage. 2019 ; Vol. 184. pp. 925-931.
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