Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas

R. L. Sorenson, D. V. Lindell, R. P. Elde

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Insulin and somatostatin release from the isolated perfused rat pancreas was studied under conditions of 50 and 300 mg/dl glucose as well as a linear 50-300 mg/dl glucose gradient. The glucose-stimulated response profile of somatostatin was nearly parallel to that of insulin in both the acute and gradient dose experiments. Antisomatostatin serum was without significant effect on glucose-stimulated insulin release. In spite of the marked, fifteenfold stimulation of somatostatin release (1.5 X 10-10 M in the perfusate effluent) by glucose, the concentration of somatostatin was insufficient to significantly alter glucose-stimulated insulin release in the isolated perfused rat pancreas.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalDiabetes
Volume29
Issue number9
DOIs
StatePublished - Jan 1 1980

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