Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

Pil Seok Chae, Rohini R. Rana, Kamil Gotfryd, Søren G.F. Rasmussen, Andrew C. Kruse, Kyung Ho Cho, Stefano Capaldi, Emil Carlsson, Brian Kobilka, Claus J. Loland, Ulrik Gether, Surajit Banerjee, Bernadette Byrne, John K. Lee, Samuel H. Gellman

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The development of a new class of surfactants for membrane protein manipulation, “GNG amphiphiles”, is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Original languageEnglish (US)
Pages (from-to)2287-2289
Number of pages3
JournalChemical Communications
Volume49
Issue number23
DOIs
StatePublished - Feb 21 2013

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