Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

Pil Seok Chae, Rohini R. Rana, Kamil Gotfryd, Søren G.F. Rasmussen, Andrew C. Kruse, Kyung Ho Cho, Stefano Capaldi, Emil Carlsson, Brian Kobilka, Claus J. Loland, Ulrik Gether, Surajit Banerjee, Bernadette Byrne, John K. Lee, Samuel H. Gellman

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


The development of a new class of surfactants for membrane protein manipulation, “GNG amphiphiles”, is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Original languageEnglish (US)
Pages (from-to)2287-2289
Number of pages3
JournalChemical Communications
Issue number23
StatePublished - Feb 21 2013


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