Glucose metabolism in mammalian cell culture: New insights for tweaking vintage pathways

Bhanu Chandra Mulukutla, Salmaan Khan, Alex Lange, Wei Shou Hu

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Cultured mammalian cells are major vehicles for producing therapeutic proteins, and energy metabolism in those cells profoundly affects process productivity. The characteristic high glucose consumption and lactate production of industrial cell lines as well as their adverse effects on productivity have been the target of both cell line and process improvement for several decades. Recent research advances have shed new light on regulation of glucose metabolism and its links to cell proliferation. This review highlights our current understanding in this area of crucial importance in bioprocessing and further discusses strategies for harnessing new findings toward process enhancement through the manipulation of cellular energy metabolism.

Original languageEnglish (US)
Pages (from-to)476-484
Number of pages9
JournalTrends in biotechnology
Volume28
Issue number9
DOIs
StatePublished - Sep 1 2010

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