Glucose 6 phosphate dehydrogenase deficiency in a dog

After screening 3,300 dogs, one animal with a mild deficiency of erythrocyte G6PD was detected. Although it had several clinical problems for 2 months, no abnormality could be directly attributable to the reduced enzymatic activity. Biochemically the mutant was electrophoretically slower but within the normal range for K(m) G6P, K(m) NADP, use of 2 dG6P and deamino NADP, pH optimum, and heat stability.