Abstract
This project originated more than 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta-testing that, fortuitously, engaged international audiences in a wide range of disciplines involved in drug discovery and development. It became clear that the inclusion of information to enhance discussions among this mix of participants would be even more valuable. The present version retains a chemical structure theme while expanding tutorial comments that aim to bridge the various perspectives that may arise during interdisciplinary communications about a given term. This glossary is intended to be educational for early stage researchers, as well as useful for investigators at various levels who participate on today's highly multidisciplinary, collaborative small molecule drug discovery teams.
Original language | English (US) |
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Pages (from-to) | 273-403 |
Number of pages | 131 |
Journal | Pure and Applied Chemistry |
Volume | 93 |
Issue number | 3 |
DOIs | |
State | Published - Feb 26 2021 |
Bibliographical note
Publisher Copyright:© 2021 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/ 2021.
Keywords
- absorption
- bioanalytical methods
- biodegradation
- drug delivery
- drug design
- drug discovery
- environmental chemistry
- enzyme chemistry
- medicinal chemistry
- metabolism
- oxidation
- pharmaceuticals