Glomerular volume in congestive cardiac failure

James D. Walker, Barbara Burke, Michael W. Siejfes, Michael Mauer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Glomerular volume has been reported to be increased in patients with congenital cyanotic heart disease and cor pulmonale; however it has not been systematically studied in patients with congestive cardiac failure (CCF). Glomerular volume was therefore measured by point-counting serially sectioned glomerular profiles of 25 randomly selected glomeruli using the Cavalieri principle in autopsy specimens from 8 patients dying from CCF and 6 age-matched controls with no renal or cardiac pathology. Mean glomerular volume was not different between patients dying from CCF and controls, 2.49 (0.21) vs. 2.25 (0.26) - 106#x03BC;m3and the distribution of individual glomerular volumes was similar in the two groups. We conclude that severe CCF is not associated with significant glomerular enlargement and that the previously reported glomerular enlargement in cyanotic heart disease is likely to be mediated through hypoxemia.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalNephron
Volume76
Issue number2
DOIs
StatePublished - Jan 1 1997

Keywords

  • Autopsy
  • Cardiac failure
  • Glomerular volume
  • Glomerulus

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