Global cognitive scores do not predict outcome after subthalamic nucleus deep brain stimulation

Darlene Floden, Robyn M. Busch, Scott E. Cooper, Cynthia S. Kubu, Andre G. Machado

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: Presence of dementia is a contraindication for DBS treatment of Parkinson's disease. Recent evidence suggests that borderline cognitive function, as measured with a common screening measure, the Mattis Dementia Rating Scale, has a negative impact on quality of life (QoL) after DBS of the STN. Methods: We attempted to replicate and extend this finding in a larger group of patients with a wider range of preoperative global cognitive performance. Results: Our data indicate that performance on the screening measure is not associated with QoL or medical outcomes, even with scores well below the cutoff for identifying dementia. Conclusions: This cognitive screening measure lacks sufficient sensitivity to warrant its use in predicting which patients will show QoL benefit from DBS.

Original languageEnglish (US)
Pages (from-to)1279-1283
Number of pages5
JournalMovement Disorders
Volume30
Issue number9
DOIs
StatePublished - Aug 1 2015

Bibliographical note

Funding Information:
D.F. has received grant funding from the National Institutes of Health (NIH; R01 NS058706‐01 and R01 NS073717‐01). R.M.B. has received grant funding from the Epilepsy Foundation (246507) and the NIH (R01 NS035929‐01; KL2TR000440). A.G.M. has served as a consultant with Spinal Modulation and Functional Neuromodulation; has received grant funding from the Department of Defense (DOD006469) and the NIH (R01 HD061363‐01); and holds distribution rights with Enspire, ATI, and Cardionomics.

Funding Information:
Portions of this research were funded by the Cleveland Clinic Center for Neurological Restoration and the National Institutes of Health (R01 NS058706‐01 [to D.F.], KL2TR000440 [to R.M.B.], and R01 HD061363‐01 [to A.G.M.]). Funding agencies:

Publisher Copyright:
© 2015 International Parkinson and Movement Disorder Society

Keywords

  • Parkinson's disease
  • cognition
  • deep brain stimulation
  • outcome research
  • quality of life

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