Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia.

Keyphrases

• Lactones 100%
• Biosynthesis Pathway 100%
• Adenylation Enzyme 100%
• Global Analysis 100%
• Nocardia 100%
• Synthetase 50%
• Biosynthetic Gene Clusters 50%
• Natural Products 33%
• Bioluminescence 16%
• Machine Learning 16%
• Web-based 16%
• Biosynthetic Pathway 16%
• Metabolic 16%
• Nonribosomal Peptide Synthesis 16%
• Carboxylic Acids 16%
• Substrate Specificity 16%
• Plant Genome 16%
• Predictive Tool 16%
• Machine Learning Approach 16%
• Gene Cluster 16%
• Specialized Functions 16%
• Protein Sequence 16%
• Enzyme Function 16%
• Bacterial Genomes 16%
• Fatty Acid Activation 16%
• Functional Classification 16%
• Life Domains 16%
• Secondary Metabolism 16%
• Product Structure 16%
• Enzyme Substrates 16%
• Divergent Evolution 16%
• Phylogenetic Reconstruction 16%
• Natural Product Discovery 16%
• Primary Metabolism 16%
• Structural Fold 16%
• Fungal Genome 16%
• Biochemical Diversity 16%
• Enzyme Scaffold 16%
• Lactone Formation 16%
• Core Enzyme 16%
• Adenylate-forming 16%
• Nocardia Brasiliensis 16%
• Succinyl-CoA Synthetase 16%
• Catalysis Reaction 16%

Biochemistry, Genetics and Molecular Biology

• Anabolism 100%
• Enzyme 100%
• Nocardia 100%
• Adenosine Monophosphate 100%
• Gene Cluster 44%
• Peptide Synthesis 11%
• Reconstruction 11%
• Peptide Sequence 11%
• Core Enzyme 11%
• Nonribosomal Peptide 11%
• Plant Genome 11%
• Enzyme Specificity 11%
• Bacterial Genome 11%
• Secondary Metabolism 11%
• Fungal Genome 11%
• Nocardia brasiliensis 11%
• Adenosine Triphosphate 11%
• Ligase 11%
• Bioluminescence 11%