The development of Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-β), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-β was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-β value in control subjects with no neurologic disease. Increased CSF TGF-β levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and AIDS dementia complex. These findings suggest that TGF-β may play an immunopathogenetic role in the CNS.
Bibliographical noteFunding Information:
From the Department of Medicine, Hennepin County Medical Center (PKP, CCC, KT); the Neuroimmunobiology and Host Defense Research Laboratory, Minneapolis Medical Research Foundation (PKP, CCC, SH); the Department of Neurology, University of Minnesota Health Sciences Center (EGS); and the University of Minnesota Medical School, Minneapolis, Minnesota. This study was supported in part by U.S. Public Health Services Grant DA-04381. Requests for reprints should be addressed to Phillip K. Peterson, M.D., Department of Medicine, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, Minnesota 55415. Manuscript submitted August 15, 1991, and accepted October 15, 1991.
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