Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis

Iris Kulbatski, Andrea J. Mothe, Ann M. Parr, Howard Kim, Catherine E. Kang, Gokhan Bozkurt, Charles H. Tator

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Traumatic injury to the brain or spinal cord and multiple sclerosis (MS) share a common pathophysiology with regard to axonal demyelination. Despite advances in central nervous system (CNS) repair in experimental animal models, adequate functional recovery has yet to be achieved in patients in response to any of the current strategies. Functional recovery is dependent, in large part, upon remyelination of spared or regenerating axons. The mammalian CNS maintains an endogenous reservoir of glial precursor cells (GPCs), capable of generating new oligodendrocytes and astrocytes. These GPCs are upregulated following traumatic or demyelinating lesions, followed by their differentiation into oligodendrocytes. However, this innate response does not adequately promote remyelination. As a result, researchers have been focusing their efforts on harvesting, culturing, characterizing, and transplanting GPCs into injured regions of the adult mammalian CNS in a variety of animal models of CNS trauma or demyelinating disease. The technical and logistic considerations for transplanting GPCs are extensive and crucial for optimizing and maintaining cell survival before and after transplantation, promoting myelination, and tracking the fate of transplanted cells. This is especially true in trials of GPC transplantation in combination with other strategies such as neutralization of inhibitors to axonal regeneration or remyelination. Overall, such studies improve our understanding and approach to developing clinically relevant therapies for axonal remyelination following traumatic brain injury (TBI) or spinal cord injury (SCI) and demyelinating diseases such as MS.

Original languageEnglish (US)
Pages (from-to)123-176
Number of pages54
JournalProgress in Histochemistry and Cytochemistry
Volume43
Issue number3
DOIs
StatePublished - Sep 10 2008

Fingerprint Dive into the research topics of 'Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis'. Together they form a unique fingerprint.

Cite this