Glial modulation of synaptic transmission in the retina

Research output: Contribution to journalReview article

108 Scopus citations

Abstract

Glial modulation of synaptic transmission and neuronal excitability in the mammalian retina is mediated by several mechanisms. Stimulation of glial cells evokes Ca2+ waves, which propagate through the network of retinal astrocytes and Müller cells and result in the modulation of the activity of neighboring ganglion cells. Light-evoked spiking is enhanced in some ganglion cells and depressed in others. A facilitation or depression of light-evoked excitatory postsynaptic currents is also seen in ganglion cells following glial stimulation. In addition, stimulation of glial cells evokes a sustained hyperpolarizing current in ganglion cells which is mediated by ATP release from Müller cells and activation of neuronal A1 adenosine receptors. Recent studies reveal that light-evoked activity in retinal neurons results in an increase in the frequency of Ca2+ transients in Müller cells. Thus, there is two-way communication between neurons and glial cells, suggesting that glia contribute to information processing in the retina.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalGlia
Volume47
Issue number3
DOIs
StatePublished - Aug 15 2004

Keywords

  • ATP
  • Astrocyte
  • Calcium wave
  • Depression
  • Enhancement
  • Glutamate
  • Müller cell
  • Neuron
  • Synapse

Fingerprint Dive into the research topics of 'Glial modulation of synaptic transmission in the retina'. Together they form a unique fingerprint.

  • Cite this