Glia instruct developmental neuronal remodeling through TGF-Î 2 signaling

Takeshi Awasaki; Yaling Huang; Michael B. O'Connor; Tzumin Lee

doi:10.1038/nn.2833

Glia instruct developmental neuronal remodeling through TGF-Î 2 signaling

Takeshi Awasaki, Yaling Huang, Michael B. O'Connor, Tzumin Lee

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

We found that glia secrete myoglianin, a TGF-β2 ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

Original language	English (US)
Pages (from-to)	821-823
Number of pages	3
Journal	Nature neuroscience
Volume	14
Issue number	7
DOIs	https://doi.org/10.1038/nn.2833
State	Published - Jul 2011

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10.1038/nn.2833

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title = "Glia instruct developmental neuronal remodeling through TGF-{\^I} 2 signaling",

abstract = "We found that glia secrete myoglianin, a TGF-β2 ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.",

author = "Takeshi Awasaki and Yaling Huang and O'Connor, \{Michael B.\} and Tzumin Lee",

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AB - We found that glia secrete myoglianin, a TGF-β2 ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

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Glia instruct developmental neuronal remodeling through TGF-Î 2 signaling

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