TY - JOUR
T1 - Ginsenosides and their metabolites
T2 - a review of their pharmacological activities in the skin
AU - Lim, Tae Gyu
AU - Lee, Charles C.
AU - Dong, Zigang
AU - Lee, Ki Won
N1 - Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2015/7/18
Y1 - 2015/7/18
N2 - Ginsenosides are representative pharmaceutical compounds found in various forms in Panax ginseng, a traditional medicinal plant. They are converted to their metabolites Rg2, Rg3, compound K, and others by human intestinal microflora following ingestion. Numerous studies have demonstrated beneficial effects of ginsenosides against aberrant molecular processes responsible for cancer, metabolic diseases and neurodegenerative diseases. Recently, antiaging effects of ginsenosides in human skin have been reported from clinical trial and in vitro model data. Ginsenosides have hence been proposed as promising natural cosmeceutical agents. In this review, we will critically review the known biological effects of several ginsenosides (Rb1, Rg3, Rd and compound K), such as anti-inflammatory and anticancer activities, which arise from the modulation of diverse molecular pathways. The application potential of ginsenosides as cosmeceutical ingredients will also be reviewed.
AB - Ginsenosides are representative pharmaceutical compounds found in various forms in Panax ginseng, a traditional medicinal plant. They are converted to their metabolites Rg2, Rg3, compound K, and others by human intestinal microflora following ingestion. Numerous studies have demonstrated beneficial effects of ginsenosides against aberrant molecular processes responsible for cancer, metabolic diseases and neurodegenerative diseases. Recently, antiaging effects of ginsenosides in human skin have been reported from clinical trial and in vitro model data. Ginsenosides have hence been proposed as promising natural cosmeceutical agents. In this review, we will critically review the known biological effects of several ginsenosides (Rb1, Rg3, Rd and compound K), such as anti-inflammatory and anticancer activities, which arise from the modulation of diverse molecular pathways. The application potential of ginsenosides as cosmeceutical ingredients will also be reviewed.
KW - Compound K
KW - Ginsenoside metabolites
KW - Rb1
KW - Rd
KW - Rg3
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U2 - 10.1007/s00403-015-1569-8
DO - 10.1007/s00403-015-1569-8
M3 - Review article
C2 - 26024573
AN - SCOPUS:84931569680
SN - 0340-3696
VL - 307
SP - 397
EP - 403
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 5
ER -