Gibberellin signal transduction presents...the SPY who O-GlcNAc'd me

Tina M. Thornton, Stephen M. Swain, Neil E Olszewski

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations


Although the molecular mechanisms by which plants respond to gibberellins are largely unknown, several components of the signal transduction pathway have been identified and a broad outline of how these components act in signal transduction is emerging. One component of the pathway, SPINDLY, is believed to be an O-GlcNAc transferase that post-translationally modifies cytosolic and nuclear proteins by the addition of O-linked N-acetylglucosamine. Although analysis of the properties of O-GlcNAc-modified proteins from animals has led to the hypothesis that this modification is regulatory, it has not been linked to specific signal transduction pathways.

Original languageEnglish (US)
Pages (from-to)424-428
Number of pages5
JournalTrends in Plant Science
Issue number11
StatePublished - Nov 1 1999

Bibliographical note

Funding Information:
This work was supported by a grant from the National Science Foundation (MCB-9604126). We thank Tong-Seung Tseng and Lynn Hartweck for helpful suggestions.


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