Giant cutaneous melanomas

Evidence for primary tumour induced dormancy in metastatic sites?

William W. Tseng, Judy A. Doyle, Sheilagh Maguiness, Andrew E. Horvai, Mohammed Kashani-Sabet, Stanley P.L. Leong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Two patients with giant, 8 cm and 19 cm melanomas of the upper extremity, respectively, are presented and discussed. Both patients had neglected their tumours and sought medical attention only after the appearance of distressing symptoms (for example, bleeding). Palpable lymph nodes were found on physical examination but no evidence of distant metastases was noted on imaging studies despite such enormous primary tumours. Both patients underwent aggressive treatment, including complete surgical resection of the primary tumour and ipsilateral axillary lymphnode dissection. One patient had no evidence of local recurrence, but developed metastatic disease at 6 months follow-up. The other patient developed local recurrence and distant metastases within 2 months of resection.

Original languageEnglish (US)
JournalBMJ case reports
DOIs
StatePublished - Oct 5 2009

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Melanoma
Skin
Neoplasms
Neoplasm Metastasis
Recurrence
Upper Extremity
Physical Examination
Dissection
Lymph Nodes
Hemorrhage
Therapeutics

Cite this

Giant cutaneous melanomas : Evidence for primary tumour induced dormancy in metastatic sites? / Tseng, William W.; Doyle, Judy A.; Maguiness, Sheilagh; Horvai, Andrew E.; Kashani-Sabet, Mohammed; Leong, Stanley P.L.

In: BMJ case reports, 05.10.2009.

Research output: Contribution to journalArticle

Tseng, William W. ; Doyle, Judy A. ; Maguiness, Sheilagh ; Horvai, Andrew E. ; Kashani-Sabet, Mohammed ; Leong, Stanley P.L. / Giant cutaneous melanomas : Evidence for primary tumour induced dormancy in metastatic sites?. In: BMJ case reports. 2009.
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