Giant cell tumour of bone

David M. Thomas, Keith M. Skubitz

Research output: Contribution to journalReview articlepeer-review

133 Scopus citations


Purpose of review: Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades. Recent findings: Recent discoveries have identified a key role for the osteoclast differentiation factor, receptor activator of nuclear factor kappa B (NF-kB) ligand (RANKL), in the genesis of GCT. The development of the fully human monoclonal antibody to RANKL, denosumab, has led to a clinical trial in unresectable GCT. This study demonstrated an 86% response rate, with comparable evidence of clinical benefit, and was well tolerated. Other pathways that may present targets for therapy include the hypoxia-angiogenesis axis and the colony stimulating factor 1 receptor. Summary: Denosumab presents a new treatment option for patients with previously untreatable GCT. The eventual role of denosumab and other targeted agents in the treatment of GCT and related disorders is currently the subject of active study.

Original languageEnglish (US)
Pages (from-to)338-344
Number of pages7
JournalCurrent Opinion in Oncology
Issue number4
StatePublished - Jul 1 2009


  • Giant cell tumour of bone
  • Osteoclast


Dive into the research topics of 'Giant cell tumour of bone'. Together they form a unique fingerprint.

Cite this