Giant cell aortitis and Noonan Syndrome

Shaji Menon, Mary E. Pierpont, David Driscoll

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An 18-year-old girl with Noonan syndrome was diagnosed with progressive aneurysmal dilatation of the ascending aorta. Histopathological examination revealed giant cell aortitis. Connective tissue abnormalities leading to aortic root dilatation and the sinuses of Valsalva aneurysm have been reported in Noonan syndrome. This report is the first description of giant cell aortitis in Noonan syndrome and may provide a link between aortic aneurysm, and giant cell granuloma of bone in Noonan syndrome.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalCongenital Heart Disease
Volume3
Issue number4
DOIs
StatePublished - Jul 1 2008

Keywords

  • Aortic aneurysm
  • Giant cell aortitis
  • Noonan syndrome

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