Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice

Amanda M. Shaw, Boman G. Irani, Marcus C. Moore, Carrie Haskell-Luevano, William J. Millard

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Ghrelin stimulates food intake in part by activating hypothalamic neuropeptide Y (NPY) neurons/agouti related peptide (AGRP) neurons. We investigated the role of AGRP/melanocortin signaling in ghrelin-induced food intake by studying melanocortin 3 and 4 receptor knockout (MC3R KO and MC4R KO) mice. We also determined whether reduced ghrelin levels and/or an altered sensitivity to the GH-stimulating effects of ghrelin accompany the obesity syndromes of MC3R KO and MC4R KO mice. Compared to wild-type (WT) mice, the effects of ghrelin on food intake were reduced in MC3R KO and MC4R KO mice and circulating ghrelin levels were reduced in female MC4R KO mice. Female MC3R KO and MC4R KO mice exhibited a diminished responsiveness to the GH-releasing effects of ghrelin. Thus, deletion of the MC3R or MC4R results in a decreased sensitivity to ghrelin and verifies the involvement in the melanocortin system in ghrelin-induced food intake.

Original languageEnglish (US)
Pages (from-to)1720-1727
Number of pages8
JournalPeptides
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • Agouti related protein
  • Ghrelin
  • Growth hormone
  • Melanocortin
  • Orexigenic

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