Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice

Min Cheol Kang, Seo Jin Park, Hei Jung Kim, Jinhee Lee, Dong Hoon Yu, Ki Beom Bae, Young Rae Ji, Si Jun Park, Jain Jeong, Woo Young Jang, Jung Hak Kim, Myung Sook Choi, Dong Seok Lee, Hyun Shik Lee, Sanggyu Lee, Sung Hyun Kim, Myoung Ok Kim, Gyeongsin Park, Yeon Sik Choo, Je Yoel ChoZae Young Ryoo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Conclusions - Conclusively, PlGF overexpression prevents angiogenesis by inhibiting Braf, extracellular signal-regulated kinase activation, and downregulation of HIF-1α in the mouse placenta. Furthermore, it affected regulatory T cells, which are important for maintenance of pregnancy.

Objective - Angiogenesis is an important biological process during development, reproduction, and in immune responses. Placental growth factor (PlGF) is a member of vascular endothelial growth factor that is critical for angiogenesis and vasculogenesis. We generated transgenic mice overexpressing PlGF in specifically T cells using the human CD2-promoter to investigate the effects of PlGF overexpression.

Approach and Results - Transgenic mice were difficult to obtain owing to high lethality; for this reason, we investigated why gestational loss occurred in these transgenic mice. Here, we report that placenta detachment and inhibition of angiogenesis occurred in PlGF transgenic mice during the gestational period. Moreover, even when transgenic mice were born, their growth was restricted.

Original languageEnglish (US)
Pages (from-to)2276-2282
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume34
Issue number10
DOIs
StatePublished - 2014

Keywords

  • BRAF kinases
  • Extracellular signal-regulated kinases
  • Miscarriage
  • Placenta growth factor
  • Regulatory T-cells

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