TY - JOUR
T1 - Gestational and postnatal age associations for striatal tissue iron deposition in early infancy
AU - Cabral, Laura
AU - Calabro, Finnegan J.
AU - Rasmussen, Jerod
AU - Foran, Will
AU - Moore, Lucille A.
AU - Graham, Alice
AU - O'Connor, Thomas G.
AU - Wadhwa, Pathik D.
AU - Entringer, Sonja
AU - Fair, Damien
AU - Buss, Claudia
AU - Panigrahy, Ashok
AU - Luna, Beatriz
N1 - Publisher Copyright:
© 2023
PY - 2023/10
Y1 - 2023/10
N2 - Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked to dopaminergic processing and cognition in children and adults. Striatal subregions have distinct functions that may come online at different time periods in early life. To identify if there are critical periods before or after birth, we measured if striatal iron accrued with gestational age at birth [range= 34.57–41.85 weeks] or postnatal age at scan [range= 5–64 days], using MRI to probe the T2* signal in N = 83 neonates in three striatal subregions. We found iron increased with postnatal age in the pallidum and putamen but not the caudate. No significant relationship between iron and gestational age was observed. Using a subset of infants scanned at preschool age (N = 26), we show distributions of iron shift between time points. In infants, the pallidum had the least iron of the three regions but had the most by preschool age. Together, this provides evidence of distinct change for striatal subregions, a possible differentiation between motor and cognitive systems, identifying a mechanism that may impact future trajectories.
AB - Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked to dopaminergic processing and cognition in children and adults. Striatal subregions have distinct functions that may come online at different time periods in early life. To identify if there are critical periods before or after birth, we measured if striatal iron accrued with gestational age at birth [range= 34.57–41.85 weeks] or postnatal age at scan [range= 5–64 days], using MRI to probe the T2* signal in N = 83 neonates in three striatal subregions. We found iron increased with postnatal age in the pallidum and putamen but not the caudate. No significant relationship between iron and gestational age was observed. Using a subset of infants scanned at preschool age (N = 26), we show distributions of iron shift between time points. In infants, the pallidum had the least iron of the three regions but had the most by preschool age. Together, this provides evidence of distinct change for striatal subregions, a possible differentiation between motor and cognitive systems, identifying a mechanism that may impact future trajectories.
KW - Development of t2 signal in infancy
KW - Early brain trajectories
KW - Striatum
KW - Subcortical development
KW - Tissue iron
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U2 - 10.1016/j.dcn.2023.101286
DO - 10.1016/j.dcn.2023.101286
M3 - Article
C2 - 37549453
AN - SCOPUS:85166934782
SN - 1878-9293
VL - 63
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
M1 - 101286
ER -