Germline De Novo Mutations as a Cause of Childhood Cancer

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4 Scopus citations

Abstract

Germline de novo mutations (DNMs) represent one of the important topics that need extensive attention from epidemiologists, geneticists, and other relevant stakeholders. Advances in next-generation sequencing technologies allowed examination of parent-offspring trios to ascertain the frequency of germline DNMs. Many epidemiological risk factors for childhood cancer are indicative of DNMs as a mechanism. The aim of this review was to give an overview of germline DNMs, their causes in general, and to discuss their relation to childhood cancer risk. In addition, we highlighted existing gaps in knowledge in many topics of germline DNMs in childhood cancer that need exploration and collaborative efforts.

Original languageEnglish (US)
JournalJCO Precision Oncology
Volume6
DOIs
StatePublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 by American Society of Clinical Oncology.

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