Geogenomic segregation and temporal trends of human pathogenic Escherichia coli o157:H7, Washington, USA, 2005-2014

Gillian A.M. Tarr, Smriti Shringi, Amanda I. Phipps, Thomas E. Besser, Jonathan Mayer, Hanna N. Oltean, Jon Wakefield, Phillip I. Tarr, Peter Rabinowitz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The often-noted and persistent increased incidence of Escherichia coli O157:H7 infections in rural areas is not well understood. We used a cohort of E. coli O157:H7 cases reported in Washington, USA, during 2005-2014, along with phylogenomic characterization of the infecting isolates, to identify geographic segregation of and temporal trends in specific phylogenetic lineages of E. coli O157:H7. Kernel estimation and generalized additive models demonstrated that pathogen lineages were spatially segregated during the period of analysis and identified a focus of segregation spanning multiple, predominantly rural, counties for each of the main clinical lineages, Ib, IIa, and IIb. These results suggest the existence of local reservoirs from which humans are infected. We also noted a secular increase in the proportion of lineage IIa and IIb isolates. Spatial segregation by phylogenetic lineage offers the potential to identify local reservoirs and intervene to prevent continued transmission.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalEmerging infectious diseases
Volume24
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health (award no. T32ES015459) and the National Institute of Allergy and Infectious Disease of the National Institutes of Health (award no. F31AI126834).

Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.

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