Genotypic and phenotypic trends in antibiotic resistant pathogenic Escherichia coli isolated from humans and farm animals in South Korea

Tatsuya Unno, Dukki Han, Jeonghwan Jang, Kenneth Widmer, Gwangpyo Ko, Michael J. Sadowsky, Hur Hor-Gil

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

South Korea uses more antibiotics for animal production than any other member of the OECD. The excessive use could potentially lead to a greater incidence of antibiotic resistant microorganisms, some of which may be pathogenic. In this study, we examined potential diarrheagenic and extraintestinal pathogenic E. coli (ExPEC) isolates using virulence gene profiling (eaeA, est, elt, ipaH, stx1 and stx2 as diarrheagenic and afa/dra, iutA, kpsMT II, papA/C, and sfa/foc as extraintestinal pathogenic virulence genes). A cluster analysis of DNA fingerprint data indicated that certain genotypes of chicken E. coli isolates are likely ExPEC. Moreover, our results showed 38 of the 60 potential diarrheagenic and ExPEC isolates obtained from animals and humans were also resistant to antibiotics, mostly to tetracycline groups, penicillin groups, and folate pathway inhibitors. Our results suggest that the use of antibiotics in agriculture should be controlled due to potential impacts on human health.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalMicrobes and environments
Volume26
Issue number3
DOIs
StatePublished - Sep 12 2011

Keywords

  • Antibiotic resistance
  • Escherichia coli
  • South Korea
  • Virulence genes

Fingerprint Dive into the research topics of 'Genotypic and phenotypic trends in antibiotic resistant pathogenic Escherichia coli isolated from humans and farm animals in South Korea'. Together they form a unique fingerprint.

  • Cite this