Abstract
To understand the evolution of swine-origin H3N2v influenza viruses that have infected 320 humans in the USA since August 2011, we performed a phylogenetic analysis at a whole genome scale of North American swine influenza viruses (n 5 200). All viral isolates evolved from the prototypical North American H3 cluster 4 (c4), with evidence for further diversification into subclusters. At least ten distinct reassorted H3N2/pandemic H1N1 (rH3N2p) genotypes were identified in swine. Genotype 1 (G1) was most frequently detected in swine and all human H3N2v viruses clustered within a single G1 clade. These data suggest that the genetic requirements for transmission to humans may be restricted to a specific subset of swine viruses. Mutations at putative antigenic sites as well as reduced serological cross-reactivity among the H3 subclusters suggest antigenic drift of these contemporary viruses.
Original language | English (US) |
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Pages (from-to) | 1236-1241 |
Number of pages | 6 |
Journal | Journal of General Virology |
Volume | 94 |
Issue number | PART 6 |
DOIs | |
State | Published - Jun 1 2013 |
Bibliographical note
Copyright:Copyright 2013 Elsevier B.V., All rights reserved.