Genotype patterns of contemporary reassorted H3N2 virus in US swine

Pravina Kitikoon, Martha I. Nelson, Mary Lea Killian, Tavis K. Anderson, Leo Koster, Marie R Culhane, Amy L. Vincent

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


To understand the evolution of swine-origin H3N2v influenza viruses that have infected 320 humans in the USA since August 2011, we performed a phylogenetic analysis at a whole genome scale of North American swine influenza viruses (n 5 200). All viral isolates evolved from the prototypical North American H3 cluster 4 (c4), with evidence for further diversification into subclusters. At least ten distinct reassorted H3N2/pandemic H1N1 (rH3N2p) genotypes were identified in swine. Genotype 1 (G1) was most frequently detected in swine and all human H3N2v viruses clustered within a single G1 clade. These data suggest that the genetic requirements for transmission to humans may be restricted to a specific subset of swine viruses. Mutations at putative antigenic sites as well as reduced serological cross-reactivity among the H3 subclusters suggest antigenic drift of these contemporary viruses.

Original languageEnglish (US)
Pages (from-to)1236-1241
Number of pages6
JournalJournal of General Virology
Issue numberPART 6
StatePublished - Jun 1 2013

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Copyright 2013 Elsevier B.V., All rights reserved.


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