Genomics in clinical practice: Lessons from the front lines

Howard J. Jacob; Kelly Abrams; David P. Bick; Kent Brodie; David P. Dimmock; Michael Farrell; Jennifer Geurts; Jeremy Harris; Daniel Helbling; Barbara J. Joers; Robert Kliegman; George Kowalski; Jozef Lazar; David A. Margolis; Paula North; Jill Northup; Altheia Roquemore-Goins; Gunter Scharer; Mary Shimoyama; Kimberly Strong; Bradley Taylor; Shirng Wern Tsaih; Michael R. Tschannen; Regan L. Veith; Jaime Wendt-Andrae; Brandon Wilk; Elizabeth A. Worthey

doi:10.1126/scitranslmed.3006468

Genomics in clinical practice: Lessons from the front lines

Howard J. Jacob
, Kelly Abrams
, David P. Bick
, Kent Brodie
, David P. Dimmock
, Michael Farrell
, Jennifer Geurts
, Jeremy Harris
, Daniel Helbling
, Barbara J. Joers
, Robert Kliegman
, George Kowalski
, Jozef Lazar
, David A. Margolis
, Paula North
, Jill Northup
, Altheia Roquemore-Goins
, Gunter Scharer
, Mary Shimoyama
, Kimberly Strong

Bradley Taylor, Shirng Wern Tsaih, Michael R. Tschannen, Regan L. Veith, Jaime Wendt-Andrae, Brandon Wilk, Elizabeth A. Worthey

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.

Original language	English (US)
Article number	194cm5
Journal	Science Translational Medicine
Volume	5
Issue number	194
DOIs	https://doi.org/10.1126/scitranslmed.3006468
State	Published - Jul 10 2013
Externally published	Yes

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10.1126/scitranslmed.3006468

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Jacob, H. J., Abrams, K., Bick, D. P., Brodie, K., Dimmock, D. P., Farrell, M., Geurts, J., Harris, J., Helbling, D., Joers, B. J., Kliegman, R., Kowalski, G., Lazar, J., Margolis, D. A., North, P., Northup, J., Roquemore-Goins, A., Scharer, G., Shimoyama, M., ... Worthey, E. A. (2013). Genomics in clinical practice: Lessons from the front lines. Science Translational Medicine, 5(194), Article 194cm5. https://doi.org/10.1126/scitranslmed.3006468

Jacob, HJ, Abrams, K, Bick, DP, Brodie, K, Dimmock, DP, Farrell, M, Geurts, J, Harris, J, Helbling, D, Joers, BJ, Kliegman, R, Kowalski, G, Lazar, J, Margolis, DA, North, P, Northup, J, Roquemore-Goins, A, Scharer, G, Shimoyama, M, Strong, K, Taylor, B, Tsaih, SW, Tschannen, MR, Veith, RL, Wendt-Andrae, J, Wilk, B & Worthey, EA 2013, 'Genomics in clinical practice: Lessons from the front lines', Science Translational Medicine, vol. 5, no. 194, 194cm5. https://doi.org/10.1126/scitranslmed.3006468

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title = "Genomics in clinical practice: Lessons from the front lines",

abstract = "The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.",

author = "Jacob, \{Howard J.\} and Kelly Abrams and Bick, \{David P.\} and Kent Brodie and Dimmock, \{David P.\} and Michael Farrell and Jennifer Geurts and Jeremy Harris and Daniel Helbling and Joers, \{Barbara J.\} and Robert Kliegman and George Kowalski and Jozef Lazar and Margolis, \{David A.\} and Paula North and Jill Northup and Altheia Roquemore-Goins and Gunter Scharer and Mary Shimoyama and Kimberly Strong and Bradley Taylor and Tsaih, \{Shirng Wern\} and Tschannen, \{Michael R.\} and Veith, \{Regan L.\} and Jaime Wendt-Andrae and Brandon Wilk and Worthey, \{Elizabeth A.\}",

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doi = "10.1126/scitranslmed.3006468",

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T2 - Lessons from the front lines

AU - Jacob, Howard J.

AU - Abrams, Kelly

AU - Bick, David P.

AU - Brodie, Kent

AU - Dimmock, David P.

AU - Farrell, Michael

AU - Geurts, Jennifer

AU - Harris, Jeremy

AU - Helbling, Daniel

AU - Joers, Barbara J.

AU - Kliegman, Robert

AU - Kowalski, George

AU - Lazar, Jozef

AU - Margolis, David A.

AU - North, Paula

AU - Northup, Jill

AU - Roquemore-Goins, Altheia

AU - Scharer, Gunter

AU - Shimoyama, Mary

AU - Strong, Kimberly

AU - Taylor, Bradley

AU - Tsaih, Shirng Wern

AU - Tschannen, Michael R.

AU - Veith, Regan L.

AU - Wendt-Andrae, Jaime

AU - Wilk, Brandon

AU - Worthey, Elizabeth A.

PY - 2013/7/10

Y1 - 2013/7/10

N2 - The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.

AB - The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.

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UR - https://www.scopus.com/pages/publications/84880547053#tab=citedBy

U2 - 10.1126/scitranslmed.3006468

DO - 10.1126/scitranslmed.3006468

M3 - Review article

C2 - 23863829

AN - SCOPUS:84880547053

SN - 1946-6234

VL - 5

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 194

M1 - 194cm5

ER -

Genomics in clinical practice: Lessons from the front lines

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