TY - JOUR
T1 - Genomics and systems biotechnology in biopharmaceutical processing
AU - Bandyopadhyay, Arpan
AU - Fu, Hsu Yuan
AU - Vishwanathan, Nandita
AU - Hu, Wei Shou
PY - 2014/11
Y1 - 2014/11
N2 - Genome-based analytical tools enable engineers to take a systems approach to bioprocessing. Proteins that require complex post-translational modifications are generally synthesized in mammalian cells because microbial hosts lack the necessary machinery to create such modifications. Many other new products being developed and tested clinically are also antibodies or antibody-based molecules, such as Fc-fusion proteins. Engineered proteins are opening up the possibility of new products with improved pharmacokinetics and efficacy.
AB - Genome-based analytical tools enable engineers to take a systems approach to bioprocessing. Proteins that require complex post-translational modifications are generally synthesized in mammalian cells because microbial hosts lack the necessary machinery to create such modifications. Many other new products being developed and tested clinically are also antibodies or antibody-based molecules, such as Fc-fusion proteins. Engineered proteins are opening up the possibility of new products with improved pharmacokinetics and efficacy.
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M3 - Article
AN - SCOPUS:84945575239
SN - 0360-7275
VL - 110
SP - 45
EP - 50
JO - Chemical Engineering Progress
JF - Chemical Engineering Progress
IS - 11
ER -