Genomics and systems biotechnology in biopharmaceutical processing

Arpan Bandyopadhyay, Hsu Yuan Fu, Nandita Vishwanathan, Wei Shou Hu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Genome-based analytical tools enable engineers to take a systems approach to bioprocessing. Proteins that require complex post-translational modifications are generally synthesized in mammalian cells because microbial hosts lack the necessary machinery to create such modifications. Many other new products being developed and tested clinically are also antibodies or antibody-based molecules, such as Fc-fusion proteins. Engineered proteins are opening up the possibility of new products with improved pharmacokinetics and efficacy.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalChemical Engineering Progress
Volume110
Issue number11
StatePublished - Nov 2014

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