Genomic sequencing and precision medicine in head and neck cancers

R. C. Hoesli; M. L. Ludwig; N. L. Michmerhuizen; A. J. Rosko; M. E. Spector; J. C. Brenner; A. C. Birkeland

doi:10.1016/j.ejso.2016.12.002

Genomic sequencing and precision medicine in head and neck cancers

R. C. Hoesli
, M. L. Ludwig
, N. L. Michmerhuizen
, A. J. Rosko
, M. E. Spector
, J. C. Brenner
, A. C. Birkeland

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.

Original language	English (US)
Pages (from-to)	884-892
Number of pages	9
Journal	European Journal of Surgical Oncology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1016/j.ejso.2016.12.002
State	Published - May 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Genomics
HNSCC
Head and neck cancer
Personalized medicine
Precision medicine

Publisher link

10.1016/j.ejso.2016.12.002

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title = "Genomic sequencing and precision medicine in head and neck cancers",

abstract = "Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.",

keywords = "Genomics, HNSCC, Head and neck cancer, Personalized medicine, Precision medicine",

author = "Hoesli, \{R. C.\} and Ludwig, \{M. L.\} and Michmerhuizen, \{N. L.\} and Rosko, \{A. J.\} and Spector, \{M. E.\} and Brenner, \{J. C.\} and Birkeland, \{A. C.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd, BASO \textasciitilde{} The Association for Cancer Surgery, and the European Society of Surgical Oncology",

year = "2017",

month = may,

doi = "10.1016/j.ejso.2016.12.002",

language = "English (US)",

volume = "43",

pages = "884--892",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

publisher = "W.B. Saunders Ltd",

number = "5",

}

TY - JOUR

T1 - Genomic sequencing and precision medicine in head and neck cancers

AU - Hoesli, R. C.

AU - Ludwig, M. L.

AU - Michmerhuizen, N. L.

AU - Rosko, A. J.

AU - Spector, M. E.

AU - Brenner, J. C.

AU - Birkeland, A. C.

PY - 2017/5

Y1 - 2017/5

N2 - Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.

AB - Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.

KW - Genomics

KW - HNSCC

KW - Head and neck cancer

KW - Personalized medicine

KW - Precision medicine

UR - https://www.scopus.com/pages/publications/85009228820

UR - https://www.scopus.com/pages/publications/85009228820#tab=citedBy

U2 - 10.1016/j.ejso.2016.12.002

DO - 10.1016/j.ejso.2016.12.002

M3 - Review article

C2 - 28034498

AN - SCOPUS:85009228820

SN - 0748-7983

VL - 43

SP - 884

EP - 892

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 5

ER -

Genomic sequencing and precision medicine in head and neck cancers

Abstract

Bibliographical note

UN SDGs

Keywords

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