Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses

K. L. Beemon, A. J. Faras, A. T. Haase

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The genetic complexities of several ribodeoxyviruses were measured by quantitative analysis of unique RNase T1 resistant oligonucleotides from 60-70S viral RNAs. Moloney murine leukemia virus was found to have an RNA complexity of 3.5x106 daltons, whereas Moloney murine sarcoma virus had a significantly smaller genome size of 2.3x106. Reticuloendotheliosis and visna virus RNAs had complexities of 3.9x106 and 3.5x106, respectively. Analysis of RNase A resistant oligonucleotides of Rous sarcoma virus RNA gave a complexity of 3.6x106, similar to that previously obtained with RNase T1 resistant oligonucleotides. Since each of these viruses was found to have a unique sequence genomic complexity near the molecular weight of a single 30-40S viral RNA sub unit, it was concluded that ribodeoxyvirus genomes are at least largely polypoid.

Original languageEnglish (US)
Pages (from-to)525-537
Number of pages13
JournalJournal of virology
Volume17
Issue number2
DOIs
StatePublished - 1976

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