Genomic analysis of the smallest giant virus - Feldmannia sp. virus 158

Declan C. Schroeder, Yunjung Park, Hong Mook Yoon, Yong Seok Lee, Se Won Kang, Russel H. Meints, Richard G. Ivey, Tae Jin Choi

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Genomic analysis of Feldmannia sp. virus 158, the second phaeovirus to be sequenced in its entirety, provides further evidence that large double-stranded DNA viruses share similar evolutionary pressures as cellular organisms. Reductive evolution is clearly evident within the phaeoviruses which occurred via several routes: the loss of genes from an ancestral virus core genome most likely through genetic drift; and as a result of relatively large recombination events that caused wholesale loss of genes. The entire genome is 154,641 bp in length and has 150 predicted coding sequences of which 87% have amino acid sequence similarities to other algal virus coding sequences within the family Phycodnaviridae. Significant similarities were found, for thirty eight coding sequences (25%), to genes in gene databanks that are known to be involved in processes that include DNA replication, DNA methylation, signal transduction, viral integration and transposition, and protein-protein interactions. Unsurprisingly, the greatest similarity was observed between the two known viruses that infect Feldmannia, indicating the taxonomic linkage of these two viruses with their hosts. Moreover, comparative analysis of phycodnaviral genomic sequences revealed the smallest set of core genes (10 out of a possible 31) required to make a functional nucleocytoplasmic large dsDNA virus.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalVirology
Volume384
Issue number1
DOIs
StatePublished - Feb 5 2009

Bibliographical note

Funding Information:
This research was supported by a grant (PF0330601-00) from the Plant Diversity Research Center of 21st Century Frontier Research Program funded by the Ministry of Science and Technology of Korean government. DCS is an MBA Research Fellow funded by grant in aid from NERC and through the NERC core strategic research programme Oceans2025 (R8-H12-52).

Keywords

  • Algae
  • Feldmannia
  • FsV
  • NCLDV
  • Phaeoviruses
  • Phycodnaviridae

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