TY - JOUR
T1 - Genome-wide multilocus analysis for immune-mediated complex diseases
AU - Lee, Jong Keuk
AU - Park, Chan
AU - Kimm, Kuchan
AU - Rutherford, Mark S.
PY - 2002/9/28
Y1 - 2002/9/28
N2 - In postgenomic era, searching and identification of disease genes associated with complex diseases are still one of the great challenge for dissecting human complex diseases. To improve the disease gene localization for complex diseases, a group of closely immune-mediated disease loci were overlapped on each chromosome based on previously reported genome-wide scanning data. Interestingly, five overlapping chromosomal regions (1q21, 2q33, 5q31.1-q33.1, 6p21, and 11q13) were identified by co-localizing disease loci for the following diseases: diabetes, asthma, atopic dermatitis, osteoporosis, and inflammatory bowel disease. The development of specific disease was associated with di7erent combinations of disease loci among five overlapped chromosomal regions. Therefore, the analysis of multiple genetic loci should be considered to determine the effects of multiple genes responsible for complex diseases resulting from the influence of multiple genes.
AB - In postgenomic era, searching and identification of disease genes associated with complex diseases are still one of the great challenge for dissecting human complex diseases. To improve the disease gene localization for complex diseases, a group of closely immune-mediated disease loci were overlapped on each chromosome based on previously reported genome-wide scanning data. Interestingly, five overlapping chromosomal regions (1q21, 2q33, 5q31.1-q33.1, 6p21, and 11q13) were identified by co-localizing disease loci for the following diseases: diabetes, asthma, atopic dermatitis, osteoporosis, and inflammatory bowel disease. The development of specific disease was associated with di7erent combinations of disease loci among five overlapped chromosomal regions. Therefore, the analysis of multiple genetic loci should be considered to determine the effects of multiple genes responsible for complex diseases resulting from the influence of multiple genes.
KW - Candidate genes
KW - Complex disease
KW - Genome-wide scan
UR - http://www.scopus.com/inward/record.url?scp=0036375827&partnerID=8YFLogxK
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U2 - 10.1016/S0006-291X(02)00679-4
DO - 10.1016/S0006-291X(02)00679-4
M3 - Article
C2 - 12127958
AN - SCOPUS:0036375827
SN - 0006-291X
VL - 295
SP - 771
EP - 773
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -