Genome-wide multilocus analysis for immune-mediated complex diseases

Jong Keuk Lee, Chan Park, Kuchan Kimm, Mark S. Rutherford

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In postgenomic era, searching and identification of disease genes associated with complex diseases are still one of the great challenge for dissecting human complex diseases. To improve the disease gene localization for complex diseases, a group of closely immune-mediated disease loci were overlapped on each chromosome based on previously reported genome-wide scanning data. Interestingly, five overlapping chromosomal regions (1q21, 2q33, 5q31.1-q33.1, 6p21, and 11q13) were identified by co-localizing disease loci for the following diseases: diabetes, asthma, atopic dermatitis, osteoporosis, and inflammatory bowel disease. The development of specific disease was associated with di7erent combinations of disease loci among five overlapped chromosomal regions. Therefore, the analysis of multiple genetic loci should be considered to determine the effects of multiple genes responsible for complex diseases resulting from the influence of multiple genes.

Original languageEnglish (US)
Pages (from-to)771-773
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume295
Issue number4
DOIs
StatePublished - Sep 28 2002

Keywords

  • Candidate genes
  • Complex disease
  • Genome-wide scan

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