Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36

Carol A. Mathews, Judith A. Badner, J. Michael Andresen, Brooke Sheppard, Joseph A. Himle, Jon E. Grant, Kyle A. Williams, Denise A. Chavira, Amin Azzam, Maxine Schwartz, Victor I. Reus, Suck Won Kim, Edwin H. Cook, Gregory L. Hanna

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background: Obsessive-compulsive disorder (OCD) has a complex etiology involving both genetic and environmental factors. However, the genetic causes of OCD are largely unknown, despite the identification of several promising candidate genes and linkage regions. Methods: Our objective was to conduct genetic linkage studies of the type of OCD thought to have the strongest genetic etiology (i.e., childhood-onset OCD), in 33 Caucasian families with <2 childhood-onset OCD-affected individuals from the United States (n = 245 individuals with genotype data). Parametric and nonparametric genome-wide linkage analyses were conducted with Morgan and Merlin in these families using a selected panel of single nucleotide repeat polymorphisms from the Illumina 610-Quad Bead Chip. The initial analyses were followed by fine-mapping analyses in genomic regions with initial heterogeneity logarithm of odds (HLOD) scores of <2.0. Results: We identified five areas of interest (HLOD score <2) on chromosomes 1p36, 2p14, 5q13, 6p25, and 10p13. The strongest result was on chromosome 1p36.33-p36.32 (HLOD = 3.77, suggestive evidence for linkage after fine mapping). At this location, several of the families showed haplotypes co-segregating with OCD. Conclusions: The results of this study represent the strongest linkage finding for OCD in a primary analysis to date and suggest that chromosome 1p36, and possibly several other genomic regions, may harbor susceptibility loci for OCD. Multiple brain-expressed genes lie under the primary linkage peak (approximately 4 megabases in size). Follow-up studies, including replication in additional samples and targeted sequencing of the areas of interest, are needed to confirm these findings and to identify specific OCD risk variants.

Original languageEnglish (US)
Pages (from-to)629-636
Number of pages8
JournalBiological psychiatry
Issue number8
StatePublished - Oct 15 2012

Bibliographical note

Funding Information:
This research was supported by grants to CAM from the National Center for Research Resources ( K23 RR015533 ), the National Alliance for Research on Schizophrenia and Affective Disorders , the Obsessive Compulsive Foundation , and the Althea Foundation ; to GLH from the National Institute of Mental Health ( K20 MH 01065 and R01 MH 58376 ) and the Obsessive Compulsive Foundation ; and to DAC from the National Institute of Mental Health ( K01 MH072952 ).


  • Genetics
  • genome-wide
  • linkage
  • multigenerational
  • obsessive-compulsive
  • pedigree


Dive into the research topics of 'Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36'. Together they form a unique fingerprint.

Cite this