Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma

Y. Sapkota; Lucie M. Turcotte; Matthew J. Ehrhardt; Rebecca M. Howell; Michael A. Arnold; Carmen L. Wilson; W. Leisenring; Zhaoming Wang; Joshua Sampson; Casey L. Dagnall; Eric Karlins; Shengchao Alfred Li; Belynda D. Hicks; Rita Weathers; Susan A. Smith; Kyla Shelton; Qi Liu; Margaret A. Tucker; Stephen J. Chanock; Jinghui Zhang; Melissa M. Hudson; Joseph P. Neglia; Gregory T. Armstrong; Leslie L. Robison; Lindsay M. Morton; S. Bhatia; Yutaka Yasui

doi:10.1016/j.jid.2019.02.029

Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma

Y. Sapkota, Lucie M. Turcotte, Matthew J. Ehrhardt, Rebecca M. Howell, Michael A. Arnold, Carmen L. Wilson, W. Leisenring, Zhaoming Wang, Joshua Sampson, Casey L. Dagnall, Eric Karlins, Shengchao Alfred Li, Belynda D. Hicks, Rita Weathers, Susan A. Smith, Kyla Shelton, Qi Liu, Margaret A. Tucker, Stephen J. Chanock, Jinghui ZhangMelissa M. Hudson, Joseph P. Neglia, Gregory T. Armstrong, Leslie L. Robison, Lindsay M. Morton, S. Bhatia, Yutaka Yasui

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Original language	English (US)
Pages (from-to)	2042-2045.e8
Journal	Journal of Investigative Dermatology
Volume	139
Issue number	9
DOIs	https://doi.org/10.1016/j.jid.2019.02.029
State	Published - Sep 2019

Bibliographical note

Funding Information:
The Childhood Cancer Survivor Study (CCSS) genome-wide association study and pooled analyses were supported by the Division of Cancer Epidemiology and Genetics, Intramural Research Program of the National Cancer Institute , National Institutes of Health . This work used the computational resources of the National Institutes of Health High-Performance Computing Biowulf cluster ( http://hpc.nih.gov ). CCSS is supported by the National Cancer Institute (CA55727: GTA, principal investigator). A portion of the CCSS genotyping also was supported by the Leukemia and Lymphoma Society (K. Kamdar, principal investigator). The St. Jude Lifetime Cohort is supported by the National Cancer Institute ( U01 CA195547 : MMH and LLR, principal investigators; Cancer Center Support CORE grant CA21765: C. Roberts, principal investigator) and the American Lebanese Syrian Associated Charities (Memphis, TN). This study is also supported by R01 CA216354 (YY and JZ, principal investigators) from the National Cancer Institute.

Funding Information:
The Childhood Cancer Survivor Study (CCSS) genome-wide association study and pooled analyses were supported by the Division of Cancer Epidemiology and Genetics, Intramural Research Program of the National Cancer Institute, National Institutes of Health. This work used the computational resources of the National Institutes of Health High-Performance Computing Biowulf cluster (http://hpc.nih.gov). CCSS is supported by the National Cancer Institute (CA55727: GTA, principal investigator). A portion of the CCSS genotyping also was supported by the Leukemia and Lymphoma Society (K. Kamdar, principal investigator). The St. Jude Lifetime Cohort is supported by the National Cancer Institute (U01 CA195547: MMH and LLR, principal investigators; Cancer Center Support CORE grant CA21765: C. Roberts, principal investigator) and the American Lebanese Syrian Associated Charities (Memphis, TN). This study is also supported by R01 CA216354 (YY and JZ, principal investigators) from the National Cancer Institute. Conceptualization: YS, LLR, LMM, SB, YY; Data Curation: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY; Formal Analysis: YS, LMT, JPN, MJE, MAA, JS, CLD, EK, SAL, BDH, MMH, GTA, LLR, LMM, YS, QL, YY; Investigation: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY; Methodology: YS, LLR, LMM, SB, YY; Project Administration: YS, CLW, ZW, CLD, EK, SAL, BDH, MAT, SJC, MMH, GTA, LLR, LMM, SB, YY; Supervision: YS, LLR, LMM, SB, YY; Validation: YS, QL; Writing - Original Draft Preparation: YS, SB, YY; Writing - Review and Editing: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY

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Sapkota, Y., Turcotte, L. M., Ehrhardt, M. J., Howell, R. M., Arnold, M. A., Wilson, C. L., Leisenring, W., Wang, Z., Sampson, J., Dagnall, C. L., Karlins, E., Li, S. A., Hicks, B. D., Weathers, R., Smith, S. A., Shelton, K., Liu, Q., Tucker, M. A., Chanock, S. J., ... Yasui, Y. (2019). Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma. Journal of Investigative Dermatology, 139(9), 2042-2045.e8. https://doi.org/10.1016/j.jid.2019.02.029

Sapkota, Y, Turcotte, LM, Ehrhardt, MJ, Howell, RM, Arnold, MA, Wilson, CL, Leisenring, W, Wang, Z, Sampson, J, Dagnall, CL, Karlins, E, Li, SA, Hicks, BD, Weathers, R, Smith, SA, Shelton, K, Liu, Q, Tucker, MA, Chanock, SJ, Zhang, J, Hudson, MM, Neglia, JP, Armstrong, GT, Robison, LL, Morton, LM, Bhatia, S & Yasui, Y 2019, 'Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma', Journal of Investigative Dermatology, vol. 139, no. 9, pp. 2042-2045.e8. https://doi.org/10.1016/j.jid.2019.02.029

@article{ddc3fe1d876a4d85a7bd0b98036f2ef0,

title = "Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma",

author = "Y. Sapkota and Turcotte, {Lucie M.} and Ehrhardt, {Matthew J.} and Howell, {Rebecca M.} and Arnold, {Michael A.} and Wilson, {Carmen L.} and W. Leisenring and Zhaoming Wang and Joshua Sampson and Dagnall, {Casey L.} and Eric Karlins and Li, {Shengchao Alfred} and Hicks, {Belynda D.} and Rita Weathers and Smith, {Susan A.} and Kyla Shelton and Qi Liu and Tucker, {Margaret A.} and Chanock, {Stephen J.} and Jinghui Zhang and Hudson, {Melissa M.} and Neglia, {Joseph P.} and Armstrong, {Gregory T.} and Robison, {Leslie L.} and Morton, {Lindsay M.} and S. Bhatia and Yutaka Yasui",

note = "Funding Information: The Childhood Cancer Survivor Study (CCSS) genome-wide association study and pooled analyses were supported by the Division of Cancer Epidemiology and Genetics, Intramural Research Program of the National Cancer Institute , National Institutes of Health . This work used the computational resources of the National Institutes of Health High-Performance Computing Biowulf cluster ( http://hpc.nih.gov ). CCSS is supported by the National Cancer Institute (CA55727: GTA, principal investigator). A portion of the CCSS genotyping also was supported by the Leukemia and Lymphoma Society (K. Kamdar, principal investigator). The St. Jude Lifetime Cohort is supported by the National Cancer Institute ( U01 CA195547 : MMH and LLR, principal investigators; Cancer Center Support CORE grant CA21765: C. Roberts, principal investigator) and the American Lebanese Syrian Associated Charities (Memphis, TN). This study is also supported by R01 CA216354 (YY and JZ, principal investigators) from the National Cancer Institute. Funding Information: The Childhood Cancer Survivor Study (CCSS) genome-wide association study and pooled analyses were supported by the Division of Cancer Epidemiology and Genetics, Intramural Research Program of the National Cancer Institute, National Institutes of Health. This work used the computational resources of the National Institutes of Health High-Performance Computing Biowulf cluster (http://hpc.nih.gov). CCSS is supported by the National Cancer Institute (CA55727: GTA, principal investigator). A portion of the CCSS genotyping also was supported by the Leukemia and Lymphoma Society (K. Kamdar, principal investigator). The St. Jude Lifetime Cohort is supported by the National Cancer Institute (U01 CA195547: MMH and LLR, principal investigators; Cancer Center Support CORE grant CA21765: C. Roberts, principal investigator) and the American Lebanese Syrian Associated Charities (Memphis, TN). This study is also supported by R01 CA216354 (YY and JZ, principal investigators) from the National Cancer Institute. Conceptualization: YS, LLR, LMM, SB, YY; Data Curation: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY; Formal Analysis: YS, LMT, JPN, MJE, MAA, JS, CLD, EK, SAL, BDH, MMH, GTA, LLR, LMM, YS, QL, YY; Investigation: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY; Methodology: YS, LLR, LMM, SB, YY; Project Administration: YS, CLW, ZW, CLD, EK, SAL, BDH, MAT, SJC, MMH, GTA, LLR, LMM, SB, YY; Supervision: YS, LLR, LMM, SB, YY; Validation: YS, QL; Writing - Original Draft Preparation: YS, SB, YY; Writing - Review and Editing: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY",

year = "2019",

month = sep,

doi = "10.1016/j.jid.2019.02.029",

language = "English (US)",

volume = "139",

pages = "2042--2045.e8",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Elsevier B.V.",

number = "9",

}

TY - JOUR

T1 - Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma

AU - Sapkota, Y.

AU - Turcotte, Lucie M.

AU - Ehrhardt, Matthew J.

AU - Howell, Rebecca M.

AU - Arnold, Michael A.

AU - Wilson, Carmen L.

AU - Leisenring, W.

AU - Wang, Zhaoming

AU - Sampson, Joshua

AU - Dagnall, Casey L.

AU - Karlins, Eric

AU - Li, Shengchao Alfred

AU - Hicks, Belynda D.

AU - Weathers, Rita

AU - Smith, Susan A.

AU - Shelton, Kyla

AU - Liu, Qi

AU - Tucker, Margaret A.

AU - Chanock, Stephen J.

AU - Zhang, Jinghui

AU - Hudson, Melissa M.

AU - Neglia, Joseph P.

AU - Armstrong, Gregory T.

AU - Robison, Leslie L.

AU - Morton, Lindsay M.

AU - Bhatia, S.

AU - Yasui, Yutaka

N1 - Funding Information: The Childhood Cancer Survivor Study (CCSS) genome-wide association study and pooled analyses were supported by the Division of Cancer Epidemiology and Genetics, Intramural Research Program of the National Cancer Institute , National Institutes of Health . This work used the computational resources of the National Institutes of Health High-Performance Computing Biowulf cluster ( http://hpc.nih.gov ). CCSS is supported by the National Cancer Institute (CA55727: GTA, principal investigator). A portion of the CCSS genotyping also was supported by the Leukemia and Lymphoma Society (K. Kamdar, principal investigator). The St. Jude Lifetime Cohort is supported by the National Cancer Institute ( U01 CA195547 : MMH and LLR, principal investigators; Cancer Center Support CORE grant CA21765: C. Roberts, principal investigator) and the American Lebanese Syrian Associated Charities (Memphis, TN). This study is also supported by R01 CA216354 (YY and JZ, principal investigators) from the National Cancer Institute. Funding Information: The Childhood Cancer Survivor Study (CCSS) genome-wide association study and pooled analyses were supported by the Division of Cancer Epidemiology and Genetics, Intramural Research Program of the National Cancer Institute, National Institutes of Health. This work used the computational resources of the National Institutes of Health High-Performance Computing Biowulf cluster (http://hpc.nih.gov). CCSS is supported by the National Cancer Institute (CA55727: GTA, principal investigator). A portion of the CCSS genotyping also was supported by the Leukemia and Lymphoma Society (K. Kamdar, principal investigator). The St. Jude Lifetime Cohort is supported by the National Cancer Institute (U01 CA195547: MMH and LLR, principal investigators; Cancer Center Support CORE grant CA21765: C. Roberts, principal investigator) and the American Lebanese Syrian Associated Charities (Memphis, TN). This study is also supported by R01 CA216354 (YY and JZ, principal investigators) from the National Cancer Institute. Conceptualization: YS, LLR, LMM, SB, YY; Data Curation: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY; Formal Analysis: YS, LMT, JPN, MJE, MAA, JS, CLD, EK, SAL, BDH, MMH, GTA, LLR, LMM, YS, QL, YY; Investigation: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY; Methodology: YS, LLR, LMM, SB, YY; Project Administration: YS, CLW, ZW, CLD, EK, SAL, BDH, MAT, SJC, MMH, GTA, LLR, LMM, SB, YY; Supervision: YS, LLR, LMM, SB, YY; Validation: YS, QL; Writing - Original Draft Preparation: YS, SB, YY; Writing - Review and Editing: YS, LMT, MJE, RMH, MAA, CLW, WL, ZW, JS, CLD, EK, SAL, BDH, RW, SAS, KS, QL, MAT, SJC, JZ, MMH, JPN, GTA, LLR, LM, SB, YY

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Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma

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