Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

David L. Morris, Yujun Sheng, Yan Zhang, Yong Fei Wang, Zhengwei Zhu, Philip Tombleson, Lingyan Chen, Deborah S. Cunninghame Graham, James Bentham, Amy L. Roberts, Ruoyan Chen, Xianbo Zuo, Tingyou Wang, Leilei Wen, Chao Yang, Lu Liu, Lulu Yang, Feng Li, Yuanbo Huang, Xianyong YinSen Yang, Lars Rönnblom, Barbara G. Fürnrohr, Reinhard E. Voll, Georg Schett, Nathalie Costedoat-Chalumeau, Patrick M. Gaffney, Yu Lung Lau, Xuejun Zhang, Wanling Yang, Yong Cui, Timothy J. Vyse

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234 Scopus citations

Abstract

Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.

Original languageEnglish (US)
Pages (from-to)940-946
Number of pages7
JournalNature Genetics
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

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© 2016 Nature America, Inc. All rights reserved.

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