TY - JOUR
T1 - Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence
AU - Sniekers, Suzanne
AU - Stringer, Sven
AU - Watanabe, Kyoko
AU - Jansen, Philip R.
AU - Coleman, Jonathan R.I.
AU - Krapohl, Eva
AU - Taskesen, Erdogan
AU - Hammerschlag, Anke R.
AU - Okbay, Aysu
AU - Zabaneh, Delilah
AU - Amin, Najaf
AU - Breen, Gerome
AU - Cesarini, David
AU - Chabris, Christopher F.
AU - Iacono, William G.
AU - Ikram, M. Arfan
AU - Johannesson, Magnus
AU - Koellinger, Philipp
AU - Lee, James J.
AU - Magnusson, Patrik K.E.
AU - McGue, Matt
AU - Miller, Mike B.
AU - Ollier, William E.R.
AU - Payton, Antony
AU - Pendleton, Neil
AU - Plomin, Robert
AU - Rietveld, Cornelius A.
AU - Tiemeier, Henning
AU - Van Duijn, Cornelia M.
AU - Posthuma, Danielle
N1 - Publisher Copyright:
© 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta- A nalysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.
AB - Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta- A nalysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.
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U2 - 10.1038/ng.3869
DO - 10.1038/ng.3869
M3 - Article
C2 - 28530673
AN - SCOPUS:85020899420
SN - 1061-4036
VL - 49
SP - 1107
EP - 1112
JO - Nature Genetics
JF - Nature Genetics
IS - 7
ER -