Genome sequences and annotation of two urinary isolates of E. coli

Travis K. Price, Arya Mehrtash, Laurynas Kalesinskas, Kema Malki, Evann E. Hilt, Catherine Putonti, Alan J. Wolfe

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The genus Escherichia includes pathogens and commensals. Bladder infections (cystitis) result most often from colonization of the bladder by uropathogenic E. coli strains. In contrast, a poorly defined condition called asymptomatic bacteriuria results from colonization of the bladder with E. coli strains without symptoms. As part of an on-going attempt to identify and characterize the newly discovered female urinary microbiota, we report the genome sequences and annotation of two urinary isolates of E. coli: one (E78) was isolated from a female patient who self-reported cystitis; the other (E75) was isolated from a female patient who reported that she did not have symptoms of cystitis. Whereas strain E75 is most closely related to an avian extraintestinal pathogen, strain E78 is a member of a clade that includes extraintestinal strains often found in the human bladder. Both genomes are uncommonly rich in prophages.

Original languageEnglish (US)
Article number79
JournalStandards in Genomic Sciences
Volume11
Issue number1
DOIs
StatePublished - Oct 12 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).

Keywords

  • Bladder
  • Enterobacteriaceae
  • Escherichia coli
  • Lower urinary tract symptoms
  • UPEC
  • Urinary tract infection

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