Genome sequence of human cytomegalovirus Ig-KG-H2, a variant of strain KG propagated in the presence of neutralizing antibodies

Ahmed Al Qaffas, Salvatore Camiolo, Jenna Nichols, Andrew J. Davison, Amine Ourahmane, Xiaohong Cui, Mark R. Schleiss, Laura Hertel, Dirk P. Dittmer, Michael A. McVoy

Research output: Contribution to journalArticlepeer-review

Abstract

Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence of several mutations in each virus.

Original languageEnglish (US)
Article numbere00063-20
JournalMicrobiology Resource Announcements
Volume9
Issue number17
DOIs
StatePublished - Apr 23 2020
Externally publishedYes

Bibliographical note

Funding Information:
We thank CSL Behring (King of Prussia, PA, USA) for the kind gift of CytoGam. This work was supported by grants R01AI088750 and R21AI073615 (National Institutes of Health; to M.A.M.), R01AI128912 (National Institutes of Health; to M.A.M. and L.H.), R01HD079918 (National Institutes of Health; to M.R.S.), P01CA019014 (National Institutes of Health; to D.P.D.), 6-FY17-849 (March of Dimes Birth Defects Foundation; to M.R.S.), 204870/Z/16/Z (Wellcome; to A.J.D.), MC_UU_12014/3 (Medical Research Council; to A.J.D.), and LKR141973 and LKRD119165 (Merck & Co.; to M.A.M.).

Funding Information:
This work was supported by grants R01AI088750 and R21AI073615 (National Institutes of Health; to M.A.M.), R01AI128912 (National Institutes of Health; to M.A.M. and L.H.), R01HD079918 (National Institutes of Health; to M.R.S.), P01CA019014 (National Institutes of Health; to D.P.D.), 6-FY17-849 (March of Dimes Birth Defects Foundation; to

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