The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and DNA specimens for 10000 vertebrate species specifically designated for whole-genome sequencing in the very near future. For this purpose, we, the Genome 10K Community of Scientists (G10KCOS), will assemble and allocate a biospecimen collection of some 16203 representative vertebrate species spanning evolutionary diversity across living mammals, birds, nonavian reptiles, amphibians, and fishes (ca. 60000 living species). In this proposal, we present precise counts for these 16203 individual species with specimens presently tagged and stipulated for DNA sequencing by the G10KCOS. DNA sequencing has ushered in a new era of investigation in the biological sciences, allowing us to embark for the first time on a truly comprehensive study of vertebrate evolution, the results of which will touch nearly every aspect of vertebrate biological enquiry.
Bibliographical noteFunding Information:
American Genetic Association, Gordon and Betty Moore Foundation, NHGRI Intramural Sequencing Center, and UCSC Alumni Association to cost of the Genome 10K workshop; Howard Hughes Medical Institute to D.H.; Gordon and Betty Moore Foundation to S.C.S.; Assembling the Euteleost Tree of Life to E.W.; National Science Foundation (0732819 to E.W., DEB-0640967 and 0543556 to J.A.M., 0817042 to H.B.S., EF0629849 to W.J.M., DEB-0443470 to G.O.); The Global Viral Forecasting Initiative to N.W., B.P., and M.L.; Biomedical Research Council of A*STAR, Singapore to B.V.; Natural Sciences and Engineering Research Council Discovery Grant to R.W.M.; National Basic Research Program of China (973 Program, 2007CB411600), the National Natural Science Foundation of China (30621092), and Bureau of Science and Technology of Yunnan Province to Y.Z.; MCB and SB RAS Programs (A.S.G.); Portuguese-American Foundation for Development, CIBIO, UP, University of Montana [G.L.] and Portuguese Science Foundation [PTDC/ CVT/69438/2006; PTDC/BIA-BDE/65625/2006 to G.L].
- Ancestral state reconstruction
- Comparative genomics
- Molecular evolution
- Species conservation
- Vertebrate biology