Genetics of prion infections

George A. Carlson; Karen Hsiao; Bruno Oesch; David Westaway; Stanley B. Prusiner

doi:10.1016/0168-9525(91)90233-G

Genetics of prion infections

George A. Carlson, Karen Hsiao, Bruno Oesch, David Westaway, Stanley B. Prusiner

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Although the infectious prions causing scrapie and several human transmissible neurodegenerative diseases resemble viruses in many respects, molecular and genetic analyses indicate that prions are fundamentally different from viruses in their structure and the mechanisms by which they cause disease. The only macromolecule that has been identified in infectious prion preparations is a disease-specific isoform of the prion protein, which is encoded by a host gene. A growing body of data supports the contention that prion infections represent a novel host-pathogen interaction.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Trends in Genetics
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0168-9525(91)90233-G
State	Published - Feb 1991
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by research grants (AG02132, NS14606 and GM37821) and a Senator Jacob Javits Center of Excellence in Neuroscience award from the NIH.

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title = "Genetics of prion infections",

abstract = "Although the infectious prions causing scrapie and several human transmissible neurodegenerative diseases resemble viruses in many respects, molecular and genetic analyses indicate that prions are fundamentally different from viruses in their structure and the mechanisms by which they cause disease. The only macromolecule that has been identified in infectious prion preparations is a disease-specific isoform of the prion protein, which is encoded by a host gene. A growing body of data supports the contention that prion infections represent a novel host-pathogen interaction.",

author = "Carlson, {George A.} and Karen Hsiao and Bruno Oesch and David Westaway and Prusiner, {Stanley B.}",

note = "Funding Information: This work was supported by research grants (AG02132, NS14606 and GM37821) and a Senator Jacob Javits Center of Excellence in Neuroscience award from the NIH.",

year = "1991",

month = feb,

doi = "10.1016/0168-9525(91)90233-G",

language = "English (US)",

volume = "7",

pages = "61--65",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Genetics of prion infections

AU - Carlson, George A.

AU - Hsiao, Karen

AU - Oesch, Bruno

AU - Westaway, David

AU - Prusiner, Stanley B.

N1 - Funding Information: This work was supported by research grants (AG02132, NS14606 and GM37821) and a Senator Jacob Javits Center of Excellence in Neuroscience award from the NIH.

PY - 1991/2

Y1 - 1991/2

N2 - Although the infectious prions causing scrapie and several human transmissible neurodegenerative diseases resemble viruses in many respects, molecular and genetic analyses indicate that prions are fundamentally different from viruses in their structure and the mechanisms by which they cause disease. The only macromolecule that has been identified in infectious prion preparations is a disease-specific isoform of the prion protein, which is encoded by a host gene. A growing body of data supports the contention that prion infections represent a novel host-pathogen interaction.

AB - Although the infectious prions causing scrapie and several human transmissible neurodegenerative diseases resemble viruses in many respects, molecular and genetic analyses indicate that prions are fundamentally different from viruses in their structure and the mechanisms by which they cause disease. The only macromolecule that has been identified in infectious prion preparations is a disease-specific isoform of the prion protein, which is encoded by a host gene. A growing body of data supports the contention that prion infections represent a novel host-pathogen interaction.

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U2 - 10.1016/0168-9525(91)90233-G

DO - 10.1016/0168-9525(91)90233-G

M3 - Review article

C2 - 1903568

AN - SCOPUS:0026054489

SN - 0168-9525

VL - 7

SP - 61

EP - 65

JO - Trends in Genetics

JF - Trends in Genetics

IS - 2

ER -

Genetics of prion infections

Abstract

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