Genetics of prion infections

George A. Carlson, Karen Hsiao, Bruno Oesch, David Westaway, Stanley B. Prusiner

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Although the infectious prions causing scrapie and several human transmissible neurodegenerative diseases resemble viruses in many respects, molecular and genetic analyses indicate that prions are fundamentally different from viruses in their structure and the mechanisms by which they cause disease. The only macromolecule that has been identified in infectious prion preparations is a disease-specific isoform of the prion protein, which is encoded by a host gene. A growing body of data supports the contention that prion infections represent a novel host-pathogen interaction.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalTrends in Genetics
Volume7
Issue number2
DOIs
StatePublished - Feb 1991
Externally publishedYes

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