Genetics of Hematopoietic Neoplasia

Diana Giannuzzi, Jaime F. Modiano, Matthew Breen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter focuses on how interactions between genes and environment impact the origin, progression, and response to therapy of hematopoietic tumors. Six essential, acquired characteristics are necessary for cellular transformation. These characteristics are: the ability to sustain proliferative signaling; the evasion of growth suppression; the ability to resist cell death; the capacity to enable reproductive immortality; the ability to induce angiogenesis; and the capacity to invade tissues and metastasize. Various models have been proposed to explain how cells acquire the features that lead to neoplastic transformation and eventually to clinical cancer. One model describes the process as stepwise accumulation of mutations that reduce constraints on growth and eventually promote transformation. Although this model is overly simplistic and technically flawed, it is nevertheless useful to convey the events that lead to carcinogenesis.

Original languageEnglish (US)
Title of host publicationSchalm's Veterinary Hematology, Seventh Edition
PublisherWiley
Pages463-470
Number of pages8
ISBN (Electronic)9781119500537
ISBN (Print)9781119500506
DOIs
StatePublished - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2022 John Wiley & Sons, Inc. All rights reserved.

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