Genetics of Equine Endocrine and Metabolic Disease

Elaine Norton, Molly McCue

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


A role for a genetic contribution to equine metabolic syndrome (EMS) and pars pituitary intermedia dysfunction (PPID) has been hypothesized. Heritability estimates of EMS biochemical measurements were consistent with moderately to highly heritable traits. Further, genome-wide association analyses have identified hundreds of regions of the genome contributing to EMS and candidate variants have been identified. The genetics of PPID has not yet been proven. Continued research for the specific genetic risk factors for both EMS and PPID is crucial for gaining a better understanding of the pathophysiology of both conditions and allowing development of genetic tests.

Original languageEnglish (US)
Pages (from-to)341-352
Number of pages12
JournalVeterinary Clinics of North America - Equine Practice
Issue number2
StatePublished - Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.


  • Equine metabolic syndrome
  • Genetics
  • Genome-wide association analysis
  • Heritability
  • Pars pituitary intermedia dysfunction
  • Risk factors

PubMed: MeSH publication types

  • Journal Article
  • Review


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