Genetics of Equine Endocrine and Metabolic Disease

Elaine Norton; Molly McCue

doi:10.1016/j.cveq.2020.03.011

Genetics of Equine Endocrine and Metabolic Disease

Elaine Norton, Molly McCue

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

A role for a genetic contribution to equine metabolic syndrome (EMS) and pars pituitary intermedia dysfunction (PPID) has been hypothesized. Heritability estimates of EMS biochemical measurements were consistent with moderately to highly heritable traits. Further, genome-wide association analyses have identified hundreds of regions of the genome contributing to EMS and candidate variants have been identified. The genetics of PPID has not yet been proven. Continued research for the specific genetic risk factors for both EMS and PPID is crucial for gaining a better understanding of the pathophysiology of both conditions and allowing development of genetic tests.

Original language	English (US)
Pages (from-to)	341-352
Number of pages	12
Journal	Veterinary Clinics of North America - Equine Practice
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.cveq.2020.03.011
State	Published - Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

Equine metabolic syndrome
Genetics
Genome-wide association analysis
Heritability
Pars pituitary intermedia dysfunction
Risk factors

PubMed: MeSH publication types

Journal Article
Review

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10.1016/j.cveq.2020.03.011

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title = "Genetics of Equine Endocrine and Metabolic Disease",

abstract = "A role for a genetic contribution to equine metabolic syndrome (EMS) and pars pituitary intermedia dysfunction (PPID) has been hypothesized. Heritability estimates of EMS biochemical measurements were consistent with moderately to highly heritable traits. Further, genome-wide association analyses have identified hundreds of regions of the genome contributing to EMS and candidate variants have been identified. The genetics of PPID has not yet been proven. Continued research for the specific genetic risk factors for both EMS and PPID is crucial for gaining a better understanding of the pathophysiology of both conditions and allowing development of genetic tests.",

keywords = "Equine metabolic syndrome, Genetics, Genome-wide association analysis, Heritability, Pars pituitary intermedia dysfunction, Risk factors",

author = "Elaine Norton and Molly McCue",

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year = "2020",

month = aug,

doi = "10.1016/j.cveq.2020.03.011",

language = "English (US)",

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T1 - Genetics of Equine Endocrine and Metabolic Disease

AU - Norton, Elaine

AU - McCue, Molly

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AB - A role for a genetic contribution to equine metabolic syndrome (EMS) and pars pituitary intermedia dysfunction (PPID) has been hypothesized. Heritability estimates of EMS biochemical measurements were consistent with moderately to highly heritable traits. Further, genome-wide association analyses have identified hundreds of regions of the genome contributing to EMS and candidate variants have been identified. The genetics of PPID has not yet been proven. Continued research for the specific genetic risk factors for both EMS and PPID is crucial for gaining a better understanding of the pathophysiology of both conditions and allowing development of genetic tests.

KW - Equine metabolic syndrome

KW - Genetics

KW - Genome-wide association analysis

KW - Heritability

KW - Pars pituitary intermedia dysfunction

KW - Risk factors

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AN - SCOPUS:85086383115

SN - 0749-0739

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JO - Veterinary Clinics of North America - Equine Practice

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ER -

Genetics of Equine Endocrine and Metabolic Disease

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

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