TY - JOUR
T1 - Genetics of diabetic retinopathy
AU - Uthra, Satagopan
AU - Raman, Rajiv
AU - Mukesh, Bickol N.
AU - Kumari, Rani Padmaja
AU - Sharma, Tarun
AU - McCarty, Catherine A.
AU - Kumaramanickavel, Govindasamy
PY - 2008
Y1 - 2008
N2 - Diabetic retinopathy (DR), a microvascular complication of diabetes in the retina, is one of the leading causes of adult blindness worldwide. Complex interplay of environmental and genetic factors has been known to contribute to its pathology. Variations in several genes have been found to be associated with risk for developing DR in different populations worldwide, which is discussed in this article. Identification of genetic variations underlining the disease would immensely lead to recognition of presymptomatic diabetic individuals susceptible to develop DR and help in planning appropriate clinical management and genetic counseling of patients.
AB - Diabetic retinopathy (DR), a microvascular complication of diabetes in the retina, is one of the leading causes of adult blindness worldwide. Complex interplay of environmental and genetic factors has been known to contribute to its pathology. Variations in several genes have been found to be associated with risk for developing DR in different populations worldwide, which is discussed in this article. Identification of genetic variations underlining the disease would immensely lead to recognition of presymptomatic diabetic individuals susceptible to develop DR and help in planning appropriate clinical management and genetic counseling of patients.
KW - Diabetic retinopathy
KW - Gene-mapping
KW - Genetic predisposition
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U2 - 10.1080/09723757.2008.11886027
DO - 10.1080/09723757.2008.11886027
M3 - Review article
AN - SCOPUS:75749119391
SN - 0972-3757
VL - 8
SP - 155
EP - 159
JO - International Journal of Human Genetics
JF - International Journal of Human Genetics
IS - 1-2
ER -