Genetically increasing flux through b-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance

Keyphrases

• Peroxisome Proliferator-activated Receptor 100%
• Skeletal muscle 100%
• Glucose Intolerance 100%
• Reductive Stress 100%
• Stress Intolerance 100%
• High-fat Diet 60%
• Redox Environment 60%
• Insulin Resistance 40%
• Whole-body 40%
• Fatty Acid Oxidation 40%
• Wild Mice 40%
• Glucose Tolerance 40%
• Mitochondrial Dysfunction 20%
• Metabolic Response 20%
• Metabolic Regulation 20%
• Insulin 20%
• Overexpressing 20%
• Homeostasis 20%
• Lipids 20%
• Genetic Model 20%
• Overexpression 20%
• Therapeutic Strategies 20%
• Mitochondrial Function 20%
• Metabolic Stress 20%
• Bioenergetics 20%
• Diet-induced 20%
• Hydrogen Peroxide 20%
• Mitochondrial Targeting 20%
• Production Rate 20%
• Energy Demand 20%
• Membrane Potential 20%
• Dystrophic Mice 20%
• Fat Mass 20%
• Catalase 20%
• Glucose Uptake 20%
• Redox State 20%
• Mitochondrial Respiration 20%
• Metabolic Demand 20%
• H2 Production 20%
• Fatty Liver 20%
• Mitochondrial Fatty Acid Oxidation 20%
• Lipid Intermediates 20%
• Muscle Glucose Uptake 20%
• Total Body Lean Mass 20%
• Mitochondrial Redox State 20%
• Toxic Lipids 20%
• Lipin-1 20%
• Energy Expenditure 20%
• Intramuscular Fatty Acids 20%
• Function States 20%
• H2O2 Emission 20%

Medicine and Dentistry

• Glucose Intolerance 100%
• Fatty Acid Oxidation 100%
• Hydrogen Peroxide 100%
• Skeletal Muscle 100%
• High Fat Food 100%
• Insulin Resistance 66%
• Glucose Uptake 66%
• Glucose Tolerance 66%
• Metabolic Regulation 33%
• Homeostasis 33%
• Energy Expenditure 33%
• Mitochondrion 33%
• Metabolic Stress 33%
• Body Fat 33%
• Fatty Liver 33%
• Catalase 33%
• Peroxisome Proliferator Activated Receptor 33%
• Mitochondrial Respiration 33%
• Membrane Potential 33%
• Mitochondrial Disorder 33%

Biochemistry, Genetics and Molecular Biology

• Beta Oxidation 100%
• Skeletal Muscle 100%
• Hydrogen Peroxide 100%
• Lipid 66%
• Glucose Transport 66%
• Wild Type Mouse 66%
• Insulin Resistance 66%
• Metabolic Pathway 33%
• Genetic Model 33%
• Catalase 33%
• Mitochondrial Disorder 33%
• Metabolic Regulation 33%
• Mitochondrial Respiration 33%
• Mitochondrion 33%
• Homeostasis 33%
• Body Fat 33%
• Energy Expenditure 33%
• Membrane Potential 33%
• Bioenergetics 33%
• Peroxisome Proliferator-Activated Receptor 33%