Genetically engineered sheep: A new paradigm for future preclinical testing of biological heart valves

Keyphrases

• Sheep 100%
• Preclinical Testing 100%
• Galactose 100%
• Biological Heart Valve 100%
• Genetically Engineered 100%
• Clinically Significant 22%
• Heart Failure Patients 11%
• Human Immune System 11%
• Biocompatibility 11%
• Physiologic 11%
• Ovine 11%
• Young Patients 11%
• Cas9 Protein 11%
• Regulatory Approval 11%
• GGTA1 11%
• Biallelic 11%
• Frameshift mutation 11%
• Tissue Processing 11%
• Galactosyltransferase 11%
• 3-galactose 11%
• Exon 4 11%
• Somatic Cell nuclear Transfer 11%
• Fetal Fibroblasts 11%
• Antigen Production 11%
• Clinical Sequelae 11%
• Spontaneous Production 11%
• Structural Valve Deterioration 11%
• Clinical Discordance 11%
• Cloned Embryo 11%
• Transcatheter 11%
• Heart Valve Prosthesis Implantation 11%
• Guide RNA (gRNA) 11%
• Heart Valve Tissue 11%
• Tissue Calcification 11%
• Xenogeneic Antigen 11%

Immunology and Microbiology

• Heart Valve 100%
• Sheep 100%
• Antigen 57%
• Somatic Cell 14%
• Nuclease 14%
• CRISPR/Cas9 14%
• Immune Response 14%
• Lamb 14%
• Cell Nucleus Transplantation 14%
• Exon 14%
• Fibroblast 14%
• Offspring 14%
• Ribonucleic Acid 14%

Medicine and Dentistry

• Heart Valve 100%
• Galactose 100%
• Antigen 40%
• Immune Response 10%
• Prematurity 10%
• Clustered Regularly Interspaced Short Palindromic Repeat 10%
• Cas9 10%
• Sequela 10%
• Biocompatibility 10%
• Nuclease 10%
• Valve Replacement 10%
• Nuclear Transfer 10%
• Guide RNA 10%
• Exon 10%
• Somatic Cell 10%
• Galactosyltransferase 10%
• Fibroblast 10%
• Offspring 10%