Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension

Russell A. Wilke, Robert U. Simpson, Bickol N. Mukesh, Satya V. Bhupathi, Richard A. Dart, Nader R. Ghebranious, Catherine A. McCarty

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Aims: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. Materials & methods: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender). Results: In the context of hypertension, a SNP in CYP27B1 was associated with congestive heart failure (odds ratio: 2.14 for subjects homozygous for the C allele; 95% CI: 1.05-4.39). Conclusion: Genetic variation in vitamin D biosynthesis is associated with increased risk of heart failure.

Original languageEnglish (US)
Pages (from-to)1789-1797
Number of pages9
JournalPharmacogenomics
Volume10
Issue number11
DOIs
StatePublished - 2009

Keywords

  • Congestive heart failure
  • Genetics
  • Hypertension
  • Vitamin D

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