DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Nov 2013|
Bibliographical noteFunding Information:
This research study was supported by the American Cancer Society Institutional Research Grant ( IRG-58-001-49-IRG41 ) and funds from the W.W. Allen-Elsa U. Pardee Foundation Chair in Cancer Biology at the University of Minnesota. The study sponsors had no involvement in study design, collection, analysis, data interpretation, manuscript preparation and decision to submit the manuscript for publication.
- Autologous transplantation
- Base excision repair
- Disease progression
- Multiple myeloma
- Nucleotide excision repair
- Single nucleotide polymorphisms