Genetic susceptibility to lung cancer-light at the end of the tunnel?

Ariela L. Marshall, David C. Christiani

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

Lung cancer is one of the most common and deadliest cancers in the world. The major socio-environmental risk factor involved in the development of lung cancer is cigarette smoking. Additionally, there are multiple genetic factors, which may also play a role in lung cancer risk. Early work focused on the presence of relatively prevalent but low-penetrance alterations in candidate genes leading to increased risk of lung cancer. Development of new technologies such as genomic profiling and genome-wide association studies has been helpful in the detection of new genetic variants likely involved in lung cancer risk. In this review, we discuss the role of multiple genetic variants and review their putative role in the risk of lung cancer. Identifying genetic biomarkers and patterns of genetic risk may be useful in the earlier detection and treatment of lung cancer patients.

Original languageEnglish (US)
Pages (from-to)487-502
Number of pages16
JournalCarcinogenesis
Volume34
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

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